Fig. 8. Model for Wg signalling through Hfp during Drosophila development. The Wg signalling pathway has a role in tissue patterning and is also required to downregulate dmyc expression and limit cell proliferation in the ZNC during wing development via repression of dmyc expression (Johnston et al., 1999). Our results suggest that Hfp may link Wg signalling to the control of cell growth and proliferation by repressing dMyc expression (see text). Wg signalling is also required to induce the domain of G2-arrested cells in the ZNC, via upregulation of achaete and scute, which in turn downregulate stg (Johnston and Edgar, 1998). Our data is consistent with Wg signalling upregulating Hfp, which would then play a role in negatively regulating stg post-transcriptionally and thereby leading to a G2-arrest.