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Fig. 2. Histological analysis and localization of maspin in early embryonic development. (A) Histological analysis of Mp+/+ and Mp–/– embryos at 5.5 dpc. (a) Mp+/+ embryo. (b,c) Abnormal Mp–/– embryos undergoing resorption. (d) Empty decidua from the implantation of presumed Mp–/– embryos. Arrows indicate the debris of the embryos. (B) Localization of maspin (a,c,e,g) and GATA4 (b,d,f,h) in early embryonic development from E4.5 to E7.5. Note that maspin is specifically expressed in the visceral endoderm from E5.5 to E7.5. GATA4 is present in the ve, pre and pe. exe, extra-embryonic endoderm; ve, visceral endoderm; ect, ectoderm; Tb, trophoblast cell; icm, inner cell mess; pe, paretial endoderm; pre, primitive endoderm.