Fig. 5. Cardiac and placental abnormalities in endothelium-specific Pdgfb knockouts. H/E staining shows cardiac (A-D) and placental (E-H) abnormalities in E18.5 lox/– embryos similar to those seen in Pdgfb^–/– embryos. Arrowheads (B,D) indicate the thin myocardium typical for –/– and lox/– animals. The placenta vessels in G and H that could be classified as either maternal or fetal by their erythrocyte content are outlined in I and J, respectively, to visualize their dilation in the lox/– animal (maternal sinuses are colored green, fetal vessels are colored purple). Scale bar in G: 10 µm.