Development -- Puelles et al. 131 (9): 2037 Figure IG1

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Fig. 1. Otx2^flox inactivation by En1-driven Cre recombinase. (A-N) En1^cre/+ and En1^cre/+; Otx2^flox/flox embryos are hybridised at E9.5 and E10.5 with Otx2 ${Delta}$ (A,B,E,H,I,L) and Cre (C,F,J,M) probes, or processed for Otx2 immunodetection (D,G,K,N). The arrows in A,D,H,K indicate the approximate position of frontal sections; the arrowheads in D,K indicate the ventral midbrain where Otx2 is lost. Fb, forebrain; Mb, midbrain; Hb, hindbrain; rp, roof plate; fp, floor plate.