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Fig. 6. Loss of Fkbp8 partially restores CNS development in the Shh-/- mutant. Wild-type (A), Shh-/- (B) and Shh-/-;Fkbp8-/- (C) littermates from an E12.5 litter are shown. Phenotype of the Shh-/- single mutant includes growth retardation, failure of limb outgrowth, severe holoprosencephaly (white arrow) and a single ventrally positioned eye. This phenotype is partially rescued in the Shh-/-;Fkbp8-/- embryo (note rescue of cyclopia and holoprosencephaly, white arrow). Other features, such as limb outgrowth defects (arrowhead), are not rescued. Scale bar: 1 mm.