Fig. 1. Reduced skeletal mineralization in Vegfa conditional knockout (CKO) mice. A comparison of the skeletons of unaffected (A,C,E,G) and Vegfa CKO (B,D,F,H) mice reveals reduced size of areas stained with Alizarin Red, suggesting reduced mineralization of mutant bones. Regions significantly affected (arrows) include the bones in hind limbs (A,B), ribs (C,D), sternum (E,F), and vertebral column (G,H).