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Fig. 8. Analysis of chondrocyte differentiation in Hif1a conditional knockout (CKO) mice. Col10a1, Ihh and Pthr1 expression domains are divided by cells that have lost the expression of these markers in the growth plates of unaffected (A,C,E) mice, while the Hif1a CKO (B,D,F) mice cells in the center of the hypertrophic domains express all three markers.