Fig. 6. TEM analysis of IFM ultrastructural morphology reveals muscle fiber degeneration, mitochondrial defects and apoptosis in parkin mutants 2 days after eclosion. (A) Control animals have well organized uniform muscle architecture and electron dense mitochondria. (B) parkin mutant muscle fibers are fragmented (arrow) and mitochondria show loss of christae (asterisk). These phenotypes are rescued with dpkR (C), but not with dpkSR transgenes (D). (E) Control animals do not show any signs of muscle death; however, parkin mutant IFMs (F) show clear signs of apoptosis, including chromatin condensation and nuclear envelope breakdown (arrows).