Fig. 7.
vß8 integrin is expressed on white matter axons in the
cerebellum. Coronal sections through the cerebellum of a five-month-old
Nestin-Cre;
vflox/+ mouse (A-I) labeled with anti-ß8 antiserum
(A,D,G) and anti-neurofilament antibody to visualize axons (B), anti-GFAP
antibody to visualize astrocytes (E), or anti-myelin antibody to visualize
oligodendrocytes (H). (E,F,I) Merged images.
vß8 integrin and
neurofilament co-localize on white matter axons (C). In white matter regions
of the cerebellum,
vß8 is not detected on GFAP-positive astrocytes
(F) or myelinating oligodendrocytes (I).