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Fig. 2. Molecular basis of osteoblast defects in Dermo1Cre; ß-cateninc/c (CKO) and Ihh-/- embryos. In situ hybridization using 35S-labeled riboprobes against Col1a1 (A-A''), AP (BB''), Runx2 (C-C'') or Osx (D-D'', E-F') on sections of humeri from wild type (A-F), CKO (A'-F') or Ihh-/- embryos (A''-D'') at E14.5 (A-D''), E15.5 (E,E') or E18.5 (F,F'). H, hypertrophic chondrocytes; L, ligament; M, marrow cavity. Asterisks indicate expression in chondrocytes. Arrowheads and arrows indicate various regions of the perichondrium (see text).