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Fig. 1. Summary of D-mib structure-function studies. All Mib proteins display the same domain structure seen in D-mib. The different domains are color-coded as follows: Mib/Herc2 domains (MH), green; zz zinc finger (ZF), orange; Mib domain, light grey; ankyrin repeats, blue; RING fingers, red. We assayed the activities of the depicted portions of D-mib in vivo and in vitro, and the results are summarized on the right; selected data are shown in Figs 2, 3, 4. Dl, Delta; Ser, Serrate.