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Fig. 5. Apoptosis in the inner ear of mgRb:Rb-/- mutants at E18.5. (A-C) In a mutant cochlea, the myosin VI-stained region of supernumerary HCs, which comprises mitotic figures (A, short arrows), shows TUNEL-(B) and cleaved caspase 3-(C) positive cells. Views are from adjacent sections. Compare with normal morphology in Fig. 2A. (D-F) TUNEL- and caspase 3-positive cells are present in the myosin VI-stained region of a hyperplastic utricular sensory epithelium. Compare with normal morphology in Fig. 3A. Long arrows indicate apoptotic profiles. Abbreviations: co, cochlea; ut, utricle; myo, myosin VI; casp, cleaved caspase 3. Scale bar: 60 µm.