Fig. 3. Amh expression in embryonic testes of single and double Sf1 and Dax1 mutants. Amh expression is localized to the primitive gonadal ridge in the wild-type male at E11.5 (A). Sf1 heterozygous gonads show early loss of Amh expression (B), but recover by E12.5 (F). Dax1 null mutant gonads also have markedly reduced Amh expression (C), followed by immediate recovery at E12.5 (G). The recovery of Amh expression is further delayed in the double mutants when compared with the single mutants (D,H).