Fig. 1. Gene expression profiling of conditional ß-catenin mutant embryos. (A) Hierarchical clustering of differentially regulated genes (see Materials and methods). The number of upregulated (shades of red) and downregulated (shades of green) genes per GeneChip is indicated. Different shades indicate the signal log ratios between the individual comparisons, and a color scale bar represents these values. (B) Enrichment of genes encoding for developmental regulatory factors among the potential ß-catenin target genes. Approximately 6000 genes on the U74Av2 GeneChip are annotated and have a gene ontology (GOID) term. The left pie chart represents the percentage of genes with the indicated GO terms among all genes with a GO term. The right pie chart represents the percentage of genes with the indicated GO terms among the 49 downregulated genes of the U74Av2 GeneChip.