Fig. 3. Specific molecular defects in Foxn1::dnFgfr2-IIIb transgenic mice. Expression of markers of the hair shaft medulla was analysed by non-radioactive in situ hybridisation in wild-type (A,C,E,G,I,K) and transgenic (B,D,F,H,J,L) hair follicles during the growth phase. Transcription of involucrin (C,D), K6hf (E,F), Sh3d19 (G,H) and Pai2 (I,J) is severely reduced in transgenic hair follicles, while expression of arachidonate 8(S) lipoxygenase (A,B) and Foxq1 (K,L) is normal. Scale bars: 100 µm.