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Fig. 2. Evolutionary history of the Snail gene superfamily. Duplication of a Snail gene in the metazoan ancestor probably gave rise to two highly related genes, Snail and Scratch. Independent duplications in Cnidarians, Protostomes and Deuterostomes gave rise to several family members in each group. Ancestral genes are shown in red and predicted members in grey, while existing genes are in black. Updated from Nieto (Nieto, 2002).