Fig. 5. Electron microscopy of liver sections shows defects in SEC and hepatocyte morphology. There is an abundance of lipid droplets (white arrowheads) in the control (A), but not in mutant (B), livers. SEM of livers shows fewer sinusoidal channels (white arrows) in the mutant (B). TEM of control (C,E) and mutant (D,F) livers reveals abnormal hepatocyte morphology, reduced hepatocyte microvilli projections (black arrows), and disrupted space of Disse (black arrowheads) in the mutant livers. SEM shows that mutant SECs lack fenestrae (H), whereas SECs in control livers are highly fenestrated (white arrowheads in G). EC, endothelial cell; L, lipid; H, hepatocyte; N, neutrophil; Er, erythrocyte; S, sinusoid.