Fig. 6. Vascular development is defective in livers that express VEGFR2T during organogenesis. The developing liver vasculature was observed by ß-galactosidase staining of ECs with the VEGFR2^lacZ allele (blue). The vasculature of control (A,C,E,G) and mutant (B,D,F,H) livers was visualized at E11.5 (A,B), E12.5 (C,D) and E13.5 (E,F), and in newborn pups (G,H). Arrows denote major blood vessels; arrowheads highlight the microvasculature (E,F). (I,J) The sinusoidal network is equally disrupted in newborn mutant livers (J) when Tet was removed at E12.5.