Fig. 7. Overexpression of SOCS and Domeless causes defective border cell migration and organization of the cluster. (A-C) Confocal micrographs of egg chambers from c306-GAL4; UAS-SOCS flies kept at 29°C, stained with STAT (green) and Armadillo (red). The border cell clusters appear to be less cohesive than normal and can exhibit reduced STAT staining (arrows). (D-F) Nomarski images of (D,E) wild-type and (F) slbo-GAL4,PZ1310;UAS-DomeCYT egg chambers. Egg chambers were stained for ß-galactosidase activity (blue). PZ1310 is an enhancer trap insertion into the slbo locus. Arrow indicates the location of the border cell cluster. (G) Graph depicting the extent of border cell migration in the indicated genotypes. For each genotype at least 50 egg chambers were examined. Scale bars: in A, 50 µm for A-C; in D, 50 µm for D-F.