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Fig. 7. Abnormal cartilage at the midline sagittal suture in Fgfr2+/S252W mice from E16.5 to E18.5. (A-D) HE staining, (E-H) Sox9 in situ hybridization, and (I-L) collagen type II immunohistochemical staining, showing the abnormal cartilage in mutants from E16.5 (left panels) to E18.5 (right panels). (A,E,I,C,G,K) Control littermates; (B,F,J,D,H,L) corresponding regions in mutant mice. Arrows, abnormal cartilage; s, skin; p, parietal bone; b, brain. Scale bars: A-L, 50 µm.