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Fig. 1. Xenopus Esr proteins are orthologs of HES proteins. Tree compares primary sequence of bHLH domain. Esr1 and Esr7 are orthologs of mouse (Mm) Hes5, zebrafish (Dr) Her4 and a chick (Gg) Hes5-like protein. Esr9 and Esr10 form a subgroup within this family. MmHes1 is homologous to Drosophila (Dm) Hairy, Xenopus laevis (Xl) Hairy2A, Gg hairy1 and DrHer6. Drosophila E(spl) proteins are shown for comparison.