Fig. 4. Expression in sensory placodes in CLGY298. (A) 8 hpf; (B) 16 hpf; (C) 24 hpf; (D) 48 hpf. Anterior is towards the left. Expression of YFP is first seen at 16 hpf in the olfactory placode (yellow arrowhead), the trigeminal placode (orange arrowhead), the inner ear (pink arrowhead) and the lateral line primordium (blue arrowhead). At 24 hours the latter three primordia migrate together before reaching their final destination, as seen at 48 hours (D). Expression is also seen in skeletal muscle early on, as well as in sensory neurons in the spinal cord.