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Fig. 10. A Wnt and Fgf8 signal are required for tubulogenesis rescue in mutant MM. (A,C,E) Embryonic spinal cord (SC) induces tubule formation in metanephric mesenchyme (MM) from control embryos (A), but not from T-Cre; Fgf8Flox/{Delta}2,3 mutant embryos (C) unless Fgf8-soaked beads are added (E). (B,D,F) Sections of cultured tissue shown on the right.