Fig. 2. Expression pattern of an NSE-Psen1 transgene. (A,B) Horizontal sections through the lateral telencephalon of an E16.5 NSE-Psen1 transgenic (A) or non-transgenic littermate control (B) embryos hybridized with a human-specific PSEN1 probe. In the transgenic embryo there is prominent hybridization in the intermediate zone (IZ), cortical plate (CP) and marginal zone (MZ), and an absence of signal in the ventricular zone (VZ). Scale bar: 50 µm.