Fig. 4. Normal appearance of the developing cortical plate in E12.5 embryos with or without Psen1. Cresyl Violet-stained horizontal sections from E12.5 wild-type (A,E) and Psen1^–/– (B,F) embryos, as well embryos with the nestin-Psen1 transgene on the Psen1^+/+ (C,G) and Psen1^–/– backgrounds (D,H). (E-H) Higher power views through the lateral wall of the telencephalon. The ventricular zone (VZ) and preplate (PP) are indicated. No differences were apparent between any of the genotypes. Scale bar: 200 µm for A-D; 25 µm for E-H.