Fig. 6. Failure of an NSE-Psen1 transgene to rescue the brain pathology in Psen1^–/– mice. Shown are Cresyl Violet-stained horizontal sections of E18.5 embryos that are wild type (A,D,G), Psen1^–/– (B,E,H) or have the NSE-Psen1 transgene on Psen1^–/– background (C,F,I). (D-I) Higher power views of the lateral cerebral wall. The embryo with the NSE-Psen1 transgene on the Psen1^–/– background exhibits multiple areas of hemorrhage (one indicated by arrow), as well as disrupted cortical lamination in a pattern that is indistinguishable from that of the Psen1^–/– embryo. Cortical layers (MZ, CP, SP, IZ) are indicated as in Fig. 5. Scale bar: 500 µm in A-C; 100 µm in D-F; 50 µm in G-I.