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Fig. 8. Mest is a potential negative regulator of an Fgf-regulated neocortical patterning pathway. (A) Genes upregulated in the Fgfr1 mutant E12.5 cortex are downregulated in the E12.5 Mest mutant cortex. Hierarchical cluster of the set of genes showing significantly different changes in gene expression between the Fgfr1 and Mest mutant cortices (P<0.05). (B) Candidate caudal neocortical patterning genes (as labelled) are downregulated in the Mest mutant cortex but upregulated in the Fgfr1 mutant cortex. Average fold changes (log base 2) from multiple independent hybridisations are shown (Mest, n=6; Fgfr1, n=9). (C) Candidate rostral neocortical patterning genes (as labelled) are upregulated in the Mest mutant cortex but downregulated in the Fgfr1 mutant cortex.