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Fig. 8. Spermiogenesis defects in Rnf17-deficient mice. (A,B) Histological analysis of seminiferous tubules in adult wild-type (A) and Rnf17-/- (B) mice at low magnifications. (C,D) Histology of wild-type and Rnf17-/- seminiferous tubules at high magnifications. White arrows, round spermatids; black arrow, an abnormal multinucleated cell. (E) Wild-type epididymal tubules (arrow) are filled with sperm. (F) Epididymal tubules (arrow) from Rnf17-/- mice lack sperm but contain spermatid-like germ cells. (G,H) Acrosomal morphology in wild-type (Stage IX) and Rnf17-deficient seminiferous tubules. Testis sections were immunostained with anti-SP10 antibodies (green) and DNA was stained with DAPI (blue). Scale bars: 25 µm.