Fig. 1. A schematic overview of TGFß signal transduction. Numbers in circles refer to specific examples given in Table 1. Abbreviations: BMP, bone morphogenetic protein; coA, co-activator; coR, co-repressor; I-Smad, inhibitory Smad; P, phosphate; Pks, protein kinases; R-Smad, receptor-regulated Smad; Txn Fac, transcription factor; Ub ligase, ubiquitin ligase. Black and green lines indicate positive interactions, red lines indicate inhibitory ones.