Fig. 2. Phenotypic defects in fibulin-1 (hd43) mutants. All panels except for G and H are oriented with dorsal up and anterior to the left. (A,B) Gonad migration in wild-type (A) and fbl-1(hd43) mutant (B) L4 hermaphrodites. Arrows indicate the position of the migrating distal tip cell; arrowheads indicate the width of the proximal gonad. (C,D) Gonad migration in wild-type (C) and fbl-1(hd43) mutant (D) L4 males. Arrows indicate the position of the stationary distal tip cell; arrowheads indicate the position of the seminal vesicle that is severed from the vas deferens and retracted to a dorsal anterior position in mutant. (E,F) Pharyngeal morphology in wild-type (E) and mutant (F) hermaphrodites. Arrows indicate the region of constriction and asymmetry in metacorpus; arrowheads show the abnormal width of the metacorpus and terminal bulb. (G,H) GFP-integrin ß pat-3 distribution in wild-type (G) and fbl-1(hd43) mutant (H) body-wall muscle. Large arrow shows region of GFP-integrin ß pat-3 accumulation at muscle-muscle junctions in wild-type animals only, and small arrows show the gaps at muscle-muscle junctions in the fbl-1(hd43) mutant. (I,J) Intestinal cells expand to fill posterior body cavity in wild-type (I) but not fbl-1(hd43) mutant (J) animals. Arrows in I and J indicate the basal surface of posterior intestinal cells. Scale bars: 10 µm.