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Fig. 8. BDNF maintains the number and density of presynaptic specializations in RGC axon terminals affected by NMDA receptor blockade. (A) APV significantly decreased GFP-synaptobrevin cluster number versus control 2 hours after treatment. Co-injection of APV and BDNF rescued GFP-synaptobrevin labeled presynaptic sites, significantly reducing the effects of APV on GFP-synaptobrevin cluster number for a period of 8 hours. (B) Total branch number was not affected by APV+ BDNF. (C) GFP-synaptobrevin cluster density was significantly decreased in the APV-treated tadpoles. BDNF maintained GFP-synaptobrevin cluster density in RGC axons co-treated with APV. The asterisks indicate significance between APV alone and APV+BDNF. (A,C) APV+BDNF is significantly different from control at the 0-4, 0-6, 0-8, 0-24 time intervals; *P≤0.05; **P≤0.005; ***P≤0.0005. n=14 axon arbors in control, n=10 in APV, n=12 in MK801 and n=11 in APV+BDNF.