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Fig. 3. Shox2 mutants exhibit clefting in the anterior palate. (A,B) Oral view of E15.0 wild-type (A) and Shox2-/- (B) palate shows an anterior clefting in the mutant. Arrows indicate the cleft. (C,D) Scanning electron microscopic images of oral view of E17.5 wild-type (C) and Shox2-/- (D) embryonic palate show an incomplete clefting (arrows) in the mutant palate. Arrow indicates the cleft, while arrowheads indicate the regions where the secondary palate fails to fuse with the primary palate and nasal septum. P, primary palate; PS, palatal shelf.