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Fig. 6. Gene expression in the Shox2-/- palatal shelves. (A) Msx1 expression in the anterior palatal mesenchyme of an E12.5 wild-type embryo. (B) Msx1 exhibits a wild-type pattern of expression in the anterior palatal mesenchyme of an E12.5 Shox2-/- embryo. (C,D) Pax9 expression is unaltered in the anterior palate of Shox2 mutant (D) when compared with wild-type control (C). (E,F) Ectopic Fgf10 expression is seen in the anterior palatal mesenchyme (arrows) of E13.5 mutant embryo (E) but not in the wild-type counterpart (F). (G,H) Fgfr2, which is restricted to the anterior palatal epithelium (arrowheads) in E13.5 wild-type embryo (G), is ectopically activated in the anterior palatal mesenchyme (arrows) of the age-matched Shox2 mutants. b, bead.