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Fig. 1. Sema3a regulates the timing of tooth innervation and dental axon guidance and patterning. Expression of Sema3a in the embryonic mandibular molar tooth germ (A1-A5) at the epithelial thickening (E11.5) (A1), early bud (E12.5) (A2), bud (E13.5) (A3), cap (E14.5) (A4) and bell (E18.5) (A5) stages compared with the localization of nerve fibers in corresponding stages of wild-type (Sema3a+/+) (B1-B5) and Sema3a null mouse embryos (Sema3a-/-) (C1-C5) using peripherin antibodies. (A1-A5) The `molar nerve' is indicated by arrows in B2. b, developing alveolar bone; cdm, condensing dental mesenchyme; cm, condensed dental mesenchyme; de, dental epithelium; dp, dental papilla mesenchyme; df, dental follicle; tn, trigeminal inferior alveolar nerve; pm, presumptive dental mesenchyme. Arrowheads mark nerve fibers. Scale bars: 100 µm.