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Fig. 3. Analysis of cell proliferation and apoptosis in the neural tube of E10.5 embryos. Coronal sections through the rostral ventral neural tube of wild-type (A-C) and megalin knockout embryos (D-F) stained with H+E (A,D), or analyzed for cell proliferation (B,E) (anti-phosphohistone H3 immunofluorescence) or apoptosis (C,F) (TUNEL assay). The number of mitotic cells is reduced in the rostroventral neural tube of the megalin–/– embryo (E, arrowheads) compared with the control (B, arrowheads). No difference is seen in the number of apoptotic nuclei in both genotypes (C,F; arrowheads).