Fig. 2. Sensitivity of the model (as measured by the guidance ratio) to its parameters. (A) Proportion of neurites competent to respond to the gradient. Response increases roughly linearly with this proportion. (B) Width of spatial averaging, i.e. effective spatial spread of signaling effects downstream from receptor binding. Note the peak at 5%. (C) Duration of temporal averaging, i.e. the time over which signaling effects decay.