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Fig. 3. Anterior-distal abnormalities in Fgfr1Co/Co;Ap-2Cre limbs. Whole-mount in situ hybridization probes were as indicated. Ages of limb buds were E11.5 (A,B,D-G), E10.5 (C) and E12.5 (H). Arrow in A indicates the enlarged anterior portion of the AER. Frozen sections of limb buds in A are shown in B. Note, samples shown in C were hybridized with probes for Fgf8 and Shh simultaneously. The red lines in D-F mark the corresponding position of truncation in mutant limbs. Wt, wild type; Mt, mutant.