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Fig. 5. Malformation of hindlimbs of Fgfr1Co/Co;Hoxb6-Cre mice. Images of E10.5 (A,C,D), E11.5 (B), E12.25 (E,F), E12.5 (G) and E14.5 (H,I) limbs. Probes used for whole-mount in situ hybridization are as indicated. Anterior is to the left and posterior to the right in all the panels. Arrows indicate the abnormal AER (B), the significantly reduced Shh expression (C), and the expanded Alx4 expression domain (D). Wt, wild type; Mt, mutant.