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Fig. 9. RA is not required for establishing the dorsoventral axis of the retina. (A-D) Whole mount in situ hybridization of E10.5 wild-type (A,C) and Aldh1a1/3-null (B,D) fetuses using digoxigenin-labeled antisense riboprobes for Tbx5 (A,B) and Vax2 (C,D). (E,F) In situ hybridization with a digoxigenin-labeled Pax2 (E,F) antisense riboprobe on frontal sections through the eye of E11.5 wild-type (E) and Aldh1a1/3-null (F) fetuses. (G,H) Distribution of apoptotic cells (assessed by TUNEL assays) in E10.5 wild-type (G) and Aldh1a1/3-null (H) fetuses. d, dorsal retina; le, lens; rpe, retinal pigment epithelium; v, ventral retina. Scale bar: 50 µm.