Fig. 3. Mutations in sem-5 but not let-60 enhanced the CAN migration defects of vab-8 mutants. The CAN positions were scored and are displayed as described in Fig. 1. The sem-5 loss-of-function allele n2019 significantly enhanced the CAN migration defects caused by the vab-8(gm84) allele (P<0.01). By contrast, the let-60 hypomorphic allele n2021, the null allele sy101sy127 and the gain-of-function allele n1046 failed to significantly enhance the CAN migration defects of vab-8(gm84) mutants (P=0.70, P=0.96 and P=0.21, respectively).