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Fig. 4. Enhancement of CAN migration defects by constitutively active EGL-15 and global egl-17 expression. The CAN positions were scored and are displayed as described in Fig. 1. (A) Global expression of egl-17 from a heat shock promoter significantly enhanced the CAN migration defects of vab-8(gm84). (B) A transgene expressing a constitutively activated EGL-15(neu) enhanced vab-8(gm84) CAN migration defects, while overexpression of wild-type egl-15 did not (P=0.39). Strains containing the transgenes were scored in a soc-2(n1774) background to avoid the lethality caused by constitutive EGL-15 activity.