Development -- Ishii et al. 132 (22): 4937 Figure IG2

(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.

Fig. 2. Defects in neural crest-derived cranial ganglia in Msx1/2 mutant embryos. (A-F) Whole-mount immunohistochemistry of neurofilament at E10.5. Control (A), Msx1/2 double homozygous (B,C,D), Msx1^–^/^–; Msx2⁺^/^– (E), and Msx1⁺^/^–; Msx2^–^/^– (F) embryos. (B-D) Double homozygous mutant embryos show a hypoplastic trigeminal nerve (V; arrows), and fused glossopharyngeal (IX) and vagus (X) nerves in the distal portion (asterisk). An abnormal connection between the trigeminal and facial (VII) nerves can be observed in Msx1/2 mutant embryos (arrowheads, B,C). Note the double-mutant embryo shown in D has impaired peripheral nerve growth and an interruption of the projection of the vagus nerve. The glossopharyngeal and vagus nerves were also fused in Msx1^–^/^–; Msx2⁺^/^– and Msx1⁺^/^–; Msx2^–^/^– embryos (asterisk, E,F). III, oculomotor nerve. Scale bar: 0.5 mm.