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Fig. 8. A constitutively active Col2-Pthr1 transgene (*PPR) was crossed into the Ext2+/– mice. Ribs of wild-type mice (A) and mice carrying the *PPR transgene (B) do not show any cartilage abnormalities. (C) Ext2+/– mice show the characteristic nodules (encircled by the broken line). (D) Introduction of the *PPR transgene does not eliminate the premature hypertrophic differentiation in the rib cartilage of Ext2+/– mice. Broken lines encircle the nodules. Scale bars: 200 µm.