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Fig. 7. Ultrastructural defects in adult Malpighian tubules of dnpc1a mutants. (A,C) Wild type; (B,D), dnpc1a mutants. (A,B) Filipin staining to show the sterol distribution in wild type and dnpc1a mutants. (C,D) Electron microscopy pictures to show large multi-lamellar structures (arrow in D) present in dnpc1a mutants but not wild-type samples.