Fig. 1. Sequence and mapping of zebrafish vps33b. (A) Deduced amino acid sequence of zebrafish and human vps33b. Identical amino acids are shaded black, similar residues in gray. VPS33B mutations from individuals with ARC are colored red (identical residue) and green (similar residue). Red lines refer to the location of ARC mutations at splice sites conserved in the zebrafish and human vps33b/VPS33B genes. (B) Map comparison of zebrafish supercontig NA54330 and human chromosome 15. Supercontig locations of vps33b and three other zebrafish genes (serf2,small EDRK-rich factor 2; mfap1, microfibrillar-associated protein 1; prc1, protein regulator of cytokinesis 1) are noted. Arrows indicate locations of the orthologous genes on human chromosome 15.