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Fig. 1. Loss of Wnt3a leads to laterality defects. (A-C) SEM micrographs of E9.5 wild-type (A) and Wnt3a-/- (B,C) hearts; mutants displayed normal (B) and inverted (situs inversus) looping (C). (D,E) E11.5 livers. Situs inversus was observed in the asymmetric arrangement of the Wnt3a-/- liver (E), compared with the control (D). (F,G) E11.5 lungs and stomach. A midline stomach and right pulmonary isomerism was often observed in mutants (G), in contrast to the wild-type lungs (F, stomach not shown). lv, left ventricle; rl, right lateral lobe; c, cranial lobe; m, medial lobe; ca, caudal lobe; a, accessory lobe; l, left lobe; st, stomach.