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Fig. 7. Wnt3a functions as a trunk organizer. The diagram depicts the ventral view of an E8 embryo. Wnt3a (red stippling) is expressed in the streak and node where it directly activates (solid blue arrows) T (brachyury), Dll1 and Axin2 via the Wnt/ß-catenin pathway. Please see the text for details. Red N, Nodal; solid blue arrow, direct gene regulation; broken blue arrow, indirect regulation; green gradient, left-sided Ca2+ flux; curved black line, negative feedback loop. Ax, axial mesendoderm.