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Fig. 8. Loss of Foxb1 expression in E12.5 Sim1/Sim2 double mutants. Coronal sections through the MB of E12.5 Sim1+/+;Sim2+/+ (A,C,E,G) and Sim1-/-;Sim2-/- (B,D,F,H) embryos were hybridized either with a Sim1 (A,B), Lhx1 (C,D), Nkx2.1 (E,F) or Foxb1 (G,H) probe. The maintenance of Sim1, Lhx1 and Nkx2.1 expression in double mutants indicates that the loss of Sim1/Sim2 does not affect the early differentiation of MB neurons. Sim1/Sim2 are, however, required to maintain Foxb1 expression in the MB.