Fig. 8. (A) Cell-autonomy and non-cell-autonomy of genes in the Nodal signaling pathway [adapted from Schier and Shen (Schier and Shen, 2000)]. (B,C) Schematic model for Cripto function in mediating Nodal activity as a cis-acting GPI-linked co-receptor (B), as well as a trans- acting soluble factor (C) [adapted from Yan et al. (Yan et al., 2002)].