Fig. 1. Three blocks of non-coding sequence are conserved among mammals and the teleost fish medaka. Intervening sequences between the Shh coding region and the Lmbr1 gene are compared between human, mouse and medaka genomes using the VISTA program. The genomic sequences used for comparison of the three species are 1,088,638 bp of human sequence (Ensemble, chromosome 7, 155013840-156102478), 992,498 bp of mouse sequence (Ensemble, chromosome 5, 26711297-27703795), and 203,199 bp of medaka fish sequence (scaffold 35). The boxes and circles depict the conserved fragments that show more than 75% identity over 100 bp of sequence among the three species. The green boxes depict the exons of Shh, and blue boxes the exons of Lmbr1. The orange circles depict conserved non-coding sequences. Notably, the Shh coding region and the conserved sequence blocks are physically linked on the same chromosomes in mouse, human, and medaka fish.